NEURAL REGENERATION RESEARCH
Vol 21｜No. 1｜January 2026
综述
Exosomes in stroke management: A promising paradigm shift in stroke therapy
外泌体在脑卒中治疗中的应用：脑卒中治疗范式有望发生转变
Bo Wang, Pinzhen Chen, Wenyan Li, Zhi Chen
NLRP3 inflammasome and gut microbiota–brain axis: A new perspective on white matter injury after intracerebral hemorrhage
NLRP3炎症小体与微生物-肠道-大脑轴：脑出血后白质损伤的新视角
Xiaoxi Cai, Xinhong Cai, Quanhua Xie, Xueqi Xiao, Tong Li, Tian Zhou, Haitao Sun
Microglial polarization pathways and therapeutic drugs targeting activated microglia in traumatic brain injury
创伤性脑损伤中活化小胶质细胞的极化途径和靶向治疗药物
Liping Shi, Shuyi Liu, Jialing Chen, Hong Wang, Zhengbo Wang
Cerebellar microglia: On the edge between neuroinflammation and neuroregulation
小脑小胶质细胞：处于神经炎症和神经调节的边缘
Marina S. Dukhinova, Jingwen Guo, Enwei Shen, Wanting Liu, Wanqi Huang, Ying Shen, Luxi Wang
Emerging role of microglia in the developing dopaminergic system: Perturbation by early life stress
小胶质细胞在多巴胺能系统发育中的新作用：早期生活压力干扰的因果效应
Kaijie She, Naijun Yuan, Minyi Huang, Wenjun Zhu, Manshi Tang, Qingyu Ma, Jiaxu Chen
Epilepsy therapy beyond neurons: Unveiling astrocytes as cellular targets
超越神经元的癫痫治疗：揭示星形胶质细胞作为细胞靶点
Yuncan Chen, Jiayi Hu, Ying Zhang, Lulu Peng, Xiaoyu Li, Cong Li, Xunyi Wu, Cong Wang
Enhanced neurogenesis after ischemic stroke: The interplay between endogenous and exogenous stem cells
缺血性卒中后神经发生增强：内源性和外源性干细胞之间的相互作用
Ruxu Geng, Yuhe Wang, Renzhi Wang, Jun Wu, Xinjie Bao
Neural functional rehabilitation: Exploring neuromuscular reconstruction technology advancements and challenges
神经功能康复：神经肌肉重建技术的进步和更严峻的挑战
Chunxiao Tang, Ping Wang, Zhonghua Li, Shizhen Zhong, Lin Yang, Guanglin Li
Dual effects of GABAAR agonist anesthetics in neurodevelopment and vulnerable brains: From neurotoxic to therapeutic effects
γ-氨基丁酸A型受体激动剂在神经发育过程中的双重效应：从神经毒性到麻醉治疗送给脆弱大脑中的 "数学难题”
Dihan Lu, Wen Zhang, Keyu Chen, Xia Feng
Current understanding and prospects for targeting neurogenesis in the treatment of cognitive impairment
以神经发生为目标治疗认知障碍的现状与前景
Ye Liu, Xibing Ding, Shushan Jia, Xiyao Gu
Investigation of epilepsy-related genes in a Drosophila model
基于果蝇模型研究癫痫的相关基因
Xiaochong Qu, Xiaodan Lai, Mingfeng He, Jinyuan Zhang, Binbin Xiang, Chuqiao Liu, Ruina Huang, Yiwu Shi, Jingda Qiao
GEMIN5 and neurodevelopmental diseases: from functional insights to disease perception
GEMIN5蛋白与神经发育疾病：从功能洞察到疾病认知
Encarnacion Martinez-Salas, Rosario Francisco-Velilla
Adiponectin as a potential mediator of the pro-cognitive effects of physical exercise on Alzheimer’s disease
脂联素作为身体锻炼对阿尔茨海默病促认知效应的潜在介导因子
Hui-Hui Guo, Hai-Ning Ou, Jia-Sui Yu, Julia Macedo Rosa, Douglas Affonso Formolo, Tong Cheng, Suk-Yu Yau, Hector Wing Hong Tsang
Synaptic and synchronic impairments in subcortical brain regions associated with early non-cognitive dysfunction in Alzheimer’s disease
与阿尔茨海默病早期非认知功能障碍相关的皮质下脑区突触性和共时性损伤
Nicolás Riffo-Lepe, Juliana González-Sanmiguel, Lorena Armijo-Weingart, Paulina Saavedra-Sieyes, David Hernandez, Gerson Ramos, Loreto S. San Martín, Luis G. Aguayo
Potential mechanisms of non-coding RNA regulation in Alzheimer’s disease
非编码 RNA 对阿尔茨海默病的内在调控机制
Yue Sun, Xinping Pang, Xudong Huang, Dinglu Liu, Jingyue Huang, Pengtao Zheng, Yanyu Wei, Chaoyang Pang
Neuronal plasticity and its role in Alzheimer’s disease and Parkinson’s disease
神经元可塑性及在阿尔茨海默病和帕金森病中的作用
Israt Jahan, Mohammad Harun-Ur-Rashid, Md. Aminul Islam, Farhana Sharmin, Soad K. Al Jaouni, Abdullah M. Kaki, Samy Selim
Hidden Face of Parkinsons Disease: Is It a New Autoimmune Disease?
帕金森病的隐藏面目：一种新的自身免疫性疾病？
Min Gi Jo, Seon-Hee Kim, Seung Pil Yun
Adeno-associated viral vectors for modeling Parkinson’s disease in non-human primates
腺相关病毒载体用于非人类灵长类动物帕金森病的建模
Julia Chocarro, José L. Lanciego
Potential biofluid markers for cognitive impairment in Parkinson’s disease
帕金森病认知功能障碍的潜在生物流体标志物
Jieyu Chen, Chunyu Liang, Fang Wang, Yongyun Zhu, Liuhui Zhu, Jianzhun Chen, Bin Liu, Xinglong Yang
Targeting the glymphatic system to promote α-synuclein clearance: A novel therapeutic strategy for Parkinson’s disease
靶向类淋巴系统促进α-突触核蛋白清除：帕金森病的新型治疗策略
Xiaoyue Lian, Zhenghao Liu, Zuobin Gan, Qingshan Yan, Luyao Tong, Linan Qiu, Yuntao Liu, Jiang-fan Chen, Zhihui Li
观点
Reprogramming induced neurons from olfactory ensheathing glial cells: a feasible approach for spinal cord injury repair
嗅鞘神经胶质细胞重编程诱导神经元：修复脊髓损伤的可行方法
Javier Sierra, María Portela-Lomba, Diana Simón, M. Teresa Moreno-Flores
Spinal cord injury-associated disruption of the autonomic immune control: does biological sex matters?
脊髓损伤后相关自主免疫控制的紊乱:生理性别重要吗?
Sara Rito-Fernandes, António J. Salgado, Nuno A. Silva, Susana Monteiro
Extra-pineal melatonin in perisynaptic Schwann cell-muscle fiber cross talk at the regenerating neuromuscular junction
再生神经肌肉接头处突触周围雪旺细胞-肌纤维串扰中的松果体外褪黑激素
Samuele Negro, Cesare Montecucco, Michela Rigoni
Cognition, apathy, and gait dysfunction in cerebral small vessel disease: a shared neural basis?
脑小血管病中的认知、冷漠和步态功能障碍：共同的神经基础？
Hao Li, Mengfei Cai, Anil Man Tuladhar
Uncovering optogenetic and chemogenetic induction of cognitive deficits: efficient techniques for manipulating and observing specific neural activities
揭示光遗传学和化学遗传学诱导的认知障碍：操纵和观察特定神经活动的有效技术
Kyoungho Suk
Aerobic exercise-induced myokine irisin release: a novel strategy to promote neuroprotection and improve cognitive function
有氧运动诱导肌动蛋白鸢尾素释放：促进神经保护和改善认知功能的新策略
Jae-Won Choi, Rengasamy Balakrishnan
Microglia and macrophages in brain injury and repair after subarachnoid hemorrhage
小胶质细胞和巨噬细胞在蛛网膜下腔出血后脑损伤和修复中的作用
David C. Lauzier, Harry V. Vinters, Shino D. Magaki
Gut microbial regulation of the oligodendrocyte lineage cell response in traumatic brain injury
肠道微生物对创伤性脑损伤中少突胶质细胞谱系细胞反应的调节
Kirill Shumilov, Stuart Friess
Shared mechanisms and pathological phenotypes underlying aminoacyl-tRNA synthetase-related neuropathies
氨酰-tRNA合成酶相关神经病变的共同机制和病理表型
Elena R. Rhymes, James N. Sleigh
Base and translation of β-glucocerebrosidase and its transporter LIMP-2 in neuropathies
β-葡萄糖脑苷脂酶及其转运体 LIMP-2 在神经病变中的基础问题与转化
Philipp Arnold, Friederike Zunke
A novel generation of potent gamma-secretase modulators: combat Alzheimers disease and Down syndrome-associated Alzheimers disease
新一代强效 γ-分泌酶调节剂:对抗阿尔茨海默病和唐氏综合征相关阿尔茨海默病
Xu-Qiao Chen
Potential Treatment of Alzheimers disease astrocyte pathology based on nuclear lipid regulation
基于核脂质调控阿尔茨海默病星形胶质细胞病理的潜在治疗方法
Masato Komai, Nobumasa Takasugi
Alpha-synuclein-induced upregulation of SKI Family Transcriptional Corepressor 1: a new player in aging & Parkinson’s disease?
α -突触核蛋白诱导SKI家族转录辅抑制因子1上调：衰老和帕金森病的新参与者？
Lauren Barrett, Rebekah Bevans, Aideen M. Sullivan, Louise M. Collins, Gerard W. O’Keeffe
P2X7 receptors and Multiple sclerosis: a potential biomarker and therapeutic target?
P2X7 受体和多发性硬化症：潜在的生物标志物和治疗靶点？
Cristina Agliardi, Franca Rosa Guerini, Mario Clerici
研究原著
脑损伤与神经再生
Neuroserpin alleviates cerebral ischemia-reperfusion injury by suppressing ischemia-induced endoplasmic reticulum stress
Neuroserpin可通过抑制内质网应激减轻缺血性脑卒中损伤
Yumei Liao, Qinghua Zhang, Qiaoyun Shi, Peng Liu, Peiyun Zhong, Lingling Guo, Zijian Huang, Yinghui Peng, Wei Liu, Shiqing Zhang, István Adorján, Yumi Fukuzaki, Eri Kawashita, Xiao-Qi Zhang, Nan Ma, Xiaoshen Zhang, Zoltán Molnár, Lei Shi
Changes in border-associated macrophages after stroke: Single-cell sequencing analysis
卒中后边界相关巨噬细胞的变化：单细胞测序分析
Ning Yu, Yang Zhao, Peng Wang, Fuqiang Zhang, Cuili Wen, Shilei Wang
神经元损伤与神经再生
Positive impact of indicaxanthin from Opuntia ficus-indica fruit on high-fat diet–induced neuronal damage and gut microbiota dysbiosis
仙人掌刺梨果实甜菜黄素对高脂饮食引起神经元损伤和肠道微生物群失调具有积极影响
Simona Terzo, Antonella Amato, Pasquale Calvi, Marta Giardina, Domenico Nuzzo, Pasquale Picone, Antonio Palumbo-Piccionello, Sara Amata, Ilenia Concetta Giardina, Alessandro Massaro, Ignazio Restivo, Alessandro Attanzio, Luisa Tesoriere, Mario Allegra, Flavia Mulè
Empowering the NSC-34 cell line as a motor neuron model: Cytosine arabinoside’s action
促进NSC-34 细胞分化为稳定而持久的神经元：阿糖胞苷的作用
Giuseppe Vitale, Susanna Amadio, Francesco Liguori, Cinzia Volonté
脊髓损伤与神经再生
Microglia overexpressing brainderived neurotrophic factor promote vascular repair and functional recovery in mice after spinal cord injury
小胶质细胞过表达脑源性神经营养因子促进小鼠脊髓损伤后血管修复和功能恢复
Fanzhuo Zeng, Yuxin Li, Xiaoyu Li, Xinyang Gu, Yue Cao, Shuai Cheng, He Tian, Rongcheng Mei, Xifan Mei
神经退行性疾病与神经再生
Chitosan alleviates symptoms of Parkinson’s disease by reducing acetate levels, which decreases inflammation and promotes repair of the intestinal barrier and blood–brain barrier
壳聚糖缓解帕金森病症状的机制：减少乙酸盐抑制炎症修复肠道和血脑屏障
Yinying Wang, Rongsha Chen, Guolin Shi, Xinwei Huang, Ke Li, Ruohua Wang, Xia Cao, Zhongshan Yang, Ninghui Zhao, Jinyuan Yan
Long noncoding RNA GAS5 acts as a competitive endogenous RNA to regulate GSK-3β and PTEN expression by sponging miR-23b-3p in Alzheimer’s disease
LncRNA GAS5调控阿尔茨海默病GSK-3β和PTEN的表达
Li Zeng, Kaiyue Zhao, Jianghong Liu, Mimin Liu, Zhongdi Cai, Ting Sun, Zhuorong Li, Rui Liu
视神经损伤与神经再生
Contribution of ferroptosis and SLC7A11 to light-induced photoreceptor degeneration
铁死亡和SLC7A11在光感受器变性中的作用
Xiaoxu Huang, Yumeng Zhang, Yuxin Jiang, Tong Li, Shiqi Yang, Yimin Wang, Bo Yu, Minwen Zhou, Guanran Zhang, Xiaohuan Zhao, Junran Sun, Xiaodong Sun
