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A research team has used the Julich-Brain Atlas to identify specific brain structures linked to antisocial behavior.
研究团队利用尤利希大脑图谱，识别出与反社会行为相关的特定脑结构。
A recent publication in the European Archives of Psychiatry and Clinical Neuroscience provides new insights into structural brain differences linked to psychopathy, a condition strongly associated with chronic violent behavior.
《欧洲精神病学与临床神经科学档案》近期发表的一项研究为与精神病态相关的大脑结构差异提供了新的见解。精神病态通常与长期暴力行为密切相关。
By applying advanced neuroimaging techniques in combination with the Julich-Brain Atlas, scientists from Forschungszentrum Jülich, RWTH Aachen University, Heinrich-Heine-University Düsseldorf, Georg August University (Germany), and the University of Pennsylvania (USA) identified distinct neural networks that show structural alterations in people with psychopathic traits.
通过将先进的神经影像技术与尤利希大脑图谱结合，来自德国尤利希研究中心、亚琛工业大学、杜塞尔多夫海因里希·海涅大学、哥廷根大学和美国宾夕法尼亚大学的科学家们识别出精神病态个体中存在结构性改变的神经网络。
The Julich-Brain Atlas is openly available through the EBRAINS Research Infrastructure.
尤利希大脑图谱可通过 EBRAINS 研究平台公开获取。
MRI confirms reduced brain volume in psychopathy
核磁共振成像确认精神病态患者大脑体积减少
The researchers analyzed structural MRI scans from 39 adult men diagnosed with psychopathy and compared them to a control group matched on key characteristics.
研究人员分析了39名被诊断为精神病态的成年男性的结构性MRI扫描结果，并与在关键特征上匹配的对照组进行了比较。
Psychopathic traits were measured using the Psychopathy Check-List (PCL-R), a widely recognized tool that distinguishes between two primary components: interpersonal-affective traits (factor 1) and lifestyle-antisocial behavior (factor 2).
精神病态特征通过广泛认可的工具——精神病态检查表（PCL-R）来衡量，该工具将精神病态分为两大因素：人际情感特质（第一因素）和生活方式/反社会行为（第二因素）。
Findings showed that individuals with higher scores on factor 2, which reflects antisocial tendencies, had reduced volumes in several brain regions.
研究发现，在第二因素得分较高的个体（反社会倾向更强）中，有多个脑区的体积明显减少。
Affected areas included subcortical structures like the basal ganglia, thalamus, and basal forebrain, as well as sections of the brainstem (pons), cerebellum, and cortical regions such as the orbitofrontal and insular cortices.
受影响区域包括基底神经节、丘脑、基底前脑等皮层下结构，以及脑干（脑桥）、小脑和一些大脑皮层区域，如眶额皮层和岛叶皮层。
These brain regions are associated with functions including emotional regulation, decision-making, impulse control, and social behavior.
这些脑区与情绪调节、决策、冲动控制及社会行为等功能密切相关。
Inconsistent links for interpersonal traits
人际特质与脑结构的关联不一致
In contrast, associations with factor 1 traits, such as pathological lying and lack of empathy, were weaker and more variable.
相比之下，与第一因素（如病态说谎、缺乏同理心）相关的大脑结构变化则较弱，差异性更大。
Some volume differences were noted in the orbitofrontal, dorsolateral-frontal, and left hippocampal areas, but the patterns were less consistent across individuals.
在眶额叶、背外侧额叶及左侧海马区域观察到一定的体积差异，但这些差异在人群中表现得并不一致。
Group comparisons also revealed a significant reduction in total brain volume in the psychopathy group, with the most notable localized difference in the right subiculum, a part of the hippocampus involved in memory.
组间比较还显示，精神病态组整体脑容量明显减少，尤其是在右侧下托海马区（subiculum）——与记忆密切相关的脑区——表现出最显著的体积下降。
The study’s authors highlight that the findings suggest a particularly strong neurobiological link between antisocial behavior and reduced brain volume across widespread regions.
研究作者强调，这些发现提示反社会行为与广泛脑区的体积减少之间存在特别强的神经生物学关联。
The study advances research on the neuropsychobiological correlates of aggression, which will be intensively investigated in the next years at RWTH Aachen together with the universities in Heidelberg and Frankfurt, the Central Institute in Mannheim, as well as Forschungszentrum Jülich within the research initiative SFB TRR 379 (Neuropsychobiology of Aggression: A Transdiagnostic Approach in Mental Disorders).
本研究推动了攻击行为神经心理生物学机制的探索。未来几年，亚琛工业大学将联合海德堡大学、法兰克福大学、曼海姆中央研究所及尤利希研究中心，在德国SFB TRR 379研究计划框架下，对“攻击行为的跨诊断神经心理生物学”进行深入研究。
Reference: “Associations of brain structure with psychopathy” by Peter Pieperhoff, Lena Hofhansel, Frank Schneider, Jürgen Müller, Katrin Amunts, Sabrina Weber-Papen, Carmen Weidler, Benjamin Clemens, Adrian Raine and Ute Habel, 29 May 2025, European Archives of Psychiatry and Clinical Neuroscience.
精选词汇
【antisocial】/ˌæn.tiˈsəʊ.ʃəl/ adj. actively hostile or harmful to society 反社会的
例句：Antisocial behaviors often include disregard for social norms.
反社会行为通常包括对社会规范的漠视。
【psychopathy】/saɪˈkɒp.ə.θi/ n. a personality disorder with antisocial traits 精神病态
例句：Psychopathy is strongly linked to chronic violence and lack of empathy.
精神病态与长期暴力和缺乏同理心密切相关。
【neuroimaging】/ˌnjʊə.rəʊˈɪm.ɪ.dʒɪŋ/ n. imaging of the brain 神经影像学
例句：Neuroimaging allows researchers to visualize brain structure abnormalities.
神经影像学使研究人员能够观察大脑结构异常。
【alteration】/ˌɔːl.təˈreɪ.ʃən/ n. the process of changing or modifying 变化，改变
例句：Structural alterations in the brain can reflect behavioral disorders.
大脑结构的变化可能反映行为障碍。
【trait】/treɪt/ n. a characteristic or quality 特征，特性
例句：Psychopathy is characterized by interpersonal and antisocial traits.
精神病态的特征包括人际和反社会特质。
【volume】/ˈvɒl.juːm/ n. the amount of space a substance occupies 体积，容量
例句：MRI scans revealed reduced brain volume in affected individuals.
MRI扫描显示相关个体脑容量减少。
【basal ganglia】/ˈbeɪ.səl ˈɡæŋ.ɡli.ə/ n. subcortical nuclei involved in movement control 基底神经节
例句：Damage to the basal ganglia can impair motor and emotional regulation.
基底神经节的损伤可能影响运动和情绪调节。
【thalamus】/ˈθæl.ə.məs/ n. relay center in the brain 丘脑
例句：The thalamus plays a key role in processing sensory information.
丘脑在处理感觉信息中起关键作用。
【orbitofrontal cortex】/ˌɔː.bɪ.təʊˈfrʌn.təl/ n. region of the prefrontal cortex near the eyes 眶额皮层
例句：The orbitofrontal cortex is critical for decision-making and emotion.
眶额皮层在决策和情绪处理中至关重要。
【insula】/ˈɪn.sjʊ.lə/ n. brain area related to emotional awareness 岛叶
例句：The insular cortex contributes to empathy and pain perception.
岛叶皮层参与同理心和疼痛感知。
【pons】/pɒnz/ n. part of the brainstem connecting the medulla and midbrain 脑桥
例句：Injury to the pons can cause severe coordination problems.
脑桥损伤可导致严重的协调障碍。
【subiculum】/səˈbɪk.jə.ləm/ n. part of the hippocampal formation associated with memory 下托海马区
例句：The subiculum is involved in memory consolidation and retrieval.
下托海马区参与记忆的巩固与提取。
【pathological】/ˌpæθ.əˈlɒdʒ.ɪ.kəl/ adj. abnormal, diseased 病理的，异常的
例句：Pathological lying is a hallmark of certain personality disorders.
病态说谎是某些人格障碍的标志。
【checklist】/ˈtʃek.lɪst/ n. a list of items for verification 检查清单
例句：The PCL-R checklist is widely used in forensic psychology.
PCL-R检查表广泛应用于司法心理学中。
【inconsistent】/ˌɪn.kənˈsɪs.tənt/ adj. not uniform or regular 不一致的，反复无常的
例句：Results for empathy-related regions were inconsistent across subjects.
同理心相关区域的结果在受试者之间并不一致。
【hippocampus】/ˌhɪp.əˈkæm.pəs/ n. brain structure involved in memory 海马体
例句：The hippocampus plays a key role in spatial and emotional memory.
海马体在空间和情绪记忆中起着关键作用。
【emotional regulation】/ɪˈməʊ.ʃən.əl ˌreɡ.jʊˈleɪ.ʃən/ n. the ability to manage emotional responses 情绪调节
例句：Impaired emotional regulation is common in psychopathic individuals.
精神病态个体常见情绪调节障碍。
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